Dihydromyricetin ufa

Dihydromyricetin ufa(DHM kapena DMY) ndi tiyi ya mpesa, chomera cha mphesa.Ili ndi ntchito zosiyanasiyana zamoyo, kuphatikizapo kuwononga ma radicals aulere m'thupi, anti-oxidation, anti-hypertension, anti-thrombus, anti-tumor, anti-inflammatory ndi zina zapadera.

Kintai ndi wopanga wamkulu wa dihydromyricetin, makamaka amatulutsa 98% ndi 30% ya dihydromyricetin yosungunuka m'madzi (zambiri zina zitha kusinthidwa). Fakitale imapanga mwachindunji ndikugulitsa, ndi mitengo yotsika mtengo kwambiri, ndi GMP, ISO, HALAL, HACCP ndi ziphaso zina. Kupyolera mu njira zotsogola komanso zoyeretsera, timapereka mankhwala opangira mankhwala, kusunga dihydromyricetin m'malo ake osungunuka m'madzi. Izi zimatsimikizira kuyamwa bwino komanso kuchita bwino pamapulogalamu osiyanasiyana. Miyezo yathu yokhazikika yowongolera khalidwe imatsimikizira kusasinthika muchiyero ndi potency, kupanga zathu Dihydromyricetin ufa chisankho chodalirika kwa mafakitale omwe akufuna zinthu zachilengedwe zapamwamba. Kaya zogwiritsidwa ntchito pazakumwa zogwira ntchito, zakudya zowonjezera, mankhwala, kapena skincare, kusungunuka kwamadzi kwapamwamba kwa mankhwala athu ndi bioavailability zimathandizira kupanga mapangidwe apamwamba kwambiri.Ngati mukufuna kuyitanitsa, chonde omasuka Lumikizanani nafe pa health@kintaibio.com.

High Potency & Clinical Efficacy
Kintai's Dihydromyricetin(CAS: 27200-12-0) imapereka chiyero chamankhwala (≥98% ndi HPLC), cholimbikitsidwa ndi ukadaulo wosungunuka m'madzi kuti ukhale ndi bioavailability yabwino. Zatsimikiziridwa kuti:

• Kuchepetsa kwa hepatoprotection (ALP/AST kuchepetsedwa ndi ≥35% m'maphunziro a preclinical).
• Thandizo la mtima kudzera mu njira za antioxidant (mtengo wa ORAC ≥5,000 μmol TE / g).
• Kuthamanga kwa kagayidwe ka mowa (acetaldehyde chilolezo ↑200% vs. placebo).
• 500% kusungunuka kwapamwamba kuposa dihydromyricetin wamba (≥50g/L m'madzi).

Multi-Industry Applications

• Zakudya Zogwira Ntchito: Zowonjezera zothandizira kukomoka (200-500mg/kapisozi) ndi zakumwa zachiwindi (0.2-1g/L).
• Mankhwala: Mapangidwe a pakamwa oteteza chiwindi (300-600mg / tsiku) ndi mafuta oletsa kutupa (1-3%).
• Zakumwa: Zakumwa zosaledzeretsa zosaledzeretsa (0.5-1.5g/L) ndi ma shoti a thanzi.
• Zodzoladzola: Mafuta oletsa kukalamba (1-5%) ndi ma seramu oteteza UV.

Kulamulira Kwawokhazikika

• Chitsimikizo Choyera: HPLC-yotsimikiziridwa ≥98% chiyero, ndi zitsulo zolemera (Pb≤1ppm, As≤0.5ppm) ndi malire a microbial (≤100CFU / g).
• Kukhazikika: mawonekedwe akristalo osungunuka m'madzi okhazikika kwa miyezi 36 (25 ℃/60% RH).
• Kutsatira: Amapangidwa m'malo olembetsedwa ndi FDA, ovomerezeka ndi GMP motsatira ISO 22000/HACCP.

Spec. & Lipoti la mayeso

                                                                               Kufotokozera kwa DHM HPLC REPORT

                                                       Lipoti loyesa la chipani chachitatu Kwa DHM heavy metal Mycotoxins lipoti loyesa kuchokera ku PONY-98% DHM

Kusungunuka kwamadzi kwa DHM Powder yathu

The solubility pazipita ndi: 335ml madzi akhoza kupasuka 500mg DHM mu 60-70 ℃. Ili ndi kusungunuka kwabwino m'madzi otentha, pafupifupi kusungunuka pa 75 ° C, ndipo palibe makhiristo omwe amatuluka pamene kutentha kumatsika mpaka kutentha.

I. Kusankha Zopangira Zopangira ndi Kukonzekera Kwambiri

Raw Material Sourcing

Timagwiritsa ntchito masamba ang'onoang'ono a Ampelopsis grossedentata (tiyi wa mpesa) wotengedwa kuzungulira Qingming Festival. Masamba aang'onowa ali ndi 20-30% DMY yochulukirapo poyerekeza ndi masamba okhwima. Zida zonse zimayesedwa mosamalitsa mankhwala ophera tizilombo ndi zitsulo zolemera, kuwonetsetsa kuti zikutsatira miyezo ya Chinese Pharmacopoeia.

Njira Yopangiratu

• Kuyanika Mwachangu: Masamba amawuma pa 60 ° C pogwiritsa ntchito mpweya wotentha mpaka chinyezi chitsike pansi pa 8%, kusunga zosakaniza zogwira ntchito.
• Kupera ndi Kuyang'anira: Masamba owuma amaphwanyidwa ndikupinidwa ndi sieve ya 40 mesh. Izi kumawonjezera pamwamba m`dera, utithandize m'zigawo Mwachangu.

II. Core Extraction Technologies

Microwave-Ethanol Synergistic Extraction (Njira Yovomerezeka)

• Kuchuluka kwa zosungunulira: Timagwiritsa ntchito 60% yankho la ethanol lachakudya lomwe lili ndi chiŵerengero cholimba chamadzimadzi cha 1:15 (g/mL).
• Kuthandizidwa ndi Microwave: Pa mphamvu ya 500W, cheza cha mphindi 50, ndi 60 ° C, mitengo yotulutsa imaposa 90%.
• Kupulumutsa Mphamvu: Dongosolo lotsekeka lotsekeka limabwezeretsanso Mowa, kutsitsa kutaya kuchepera 5%.

Kutulutsa Kwamadzi Kokwanira (Njira Yotsika mtengo)

• Kuchotsa Madzi Oyera: Pogwiritsa ntchito chiŵerengero cha 1:20 cholimba-chamadzimadzi, kuwira pa 80 ° C kwa maola awiri kumapindula ndi 85% yochotsa.
• Dynamic Countercurrent Extraction: Matanki ochotsa magawo atatu amachepetsa kugwiritsa ntchito zosungunulira ndi 30%.

III. Kuyeretsedwa ndi Kukonzanso

Kuyeretsedwa Kwambiri

• Kuyika kwa Vacuum: Zotulutsa zimakhazikika pa 40 ° C pansi pa vacuum. Madzi owonongeka ndi BOD <100 amalowa m'dongosolo lathu lamankhwala.
• pH Mvula: Kuonjezera madzi ozizira (pH = 6) kumabweretsa zonyansa, kutsatiridwa ndi decolorization ndi activated carbon.

Kuyeretsedwa Kwambiri

• Macroporous Resin Chromatography: AB-8 resin yokhala ndi ethanol gradient elution imakulitsa chiyero mpaka 95%.
• Low-Temperature Recrystallization: Mizere iwiri yokonzanso mu 4: 1 ethanol-madzi system imatulutsa zinthu zokhala ndi ≥98% chiyero ndi 75% kuchira.

IV. Kuwongolera Ubwino ndi Kusintha Kwatsopano

Kuwunika pa intaneti

HPLC imayang'anira mosalekeza zomwe zili mu DMY, kuwonetsetsa kusasinthika (RSD<2%).

Kupititsa patsogolo Zotuluka

• Esterification: Kuchita DMY ndi linoleic acid kumapanga DMY linoleate, kumapangitsa kusungunuka kwa lipid ndi antioxidant katundu.
• Mapangidwe Osungunuka M'madzi: Kuphatikiza ndi PVP K30 kumapangitsa DMY kusungunuka m'madzi, kukulitsa kugwiritsidwa ntchito kwake muzodzola.

1. Antioxidant: Ndi kuchuluka kwa chiyero cha dihydromyricetin, mphamvu ya antioxidant imakulitsidwa, yomwe imatha kuyeretsa ma radicals aulere m'thupi, kuchepetsa kuwonongeka komwe kumachitika chifukwa cha ma free radicals m'maselo ndi minofu, motero kuchedwetsa kukalamba, ndipo kumakhala ndi antioxidant wamphamvu pa nyama. mafuta ndi masamba mafuta.

2.Tetezani Chiwindi: Dihydromyricetin imatha kulimbikitsa kuwonongeka kwa metabolites ya ethanol, imathandizira kukana kuledzera komanso kudalira mowa, kuchepetsa kuwonongeka kwa mowa m'chiwindi, kukonza kuwonongeka kwa maselo a chiwindi, kuletsa kuwonongeka kwa maselo a chiwindi, ndikuthandizira kuteteza chiwindi.

3. Antibacterial Effect: Kuyesera kwawonetsa kuti dihydromyricetin imakhala ndi antibacterial effect pa Bacillus subtilis, Staphylococcus aureus, salmonella ndi mabakiteriya ena, ndipo antibacterial effect ndi yolimba kwambiri mu pH3 ~ 4 chilengedwe, koma zolepheretsa pa bowa sizodziwikiratu.4. Zotsatira za Antitumor: Kafukufuku wasonyeza kuti dihydromycetin imatha kusintha bwino zotsatira za chithandizo cha chotupa ndikuwongolera zizindikiro zofunika za odwala poletsa chotupa angiogenesis ndikusintha ndi kupititsa patsogolo chitetezo cham'thupi. M'maphunziro oyesera pamitundu yotupa monga khansa ya m'magazi ndi nasopharyngeal carcinoma, yawonetsa ntchito yolimbana ndi chotupa, yomwe imapereka njira yatsopano komanso chiyembekezo cha chithandizo cha chotupa.

Pakalipano, dihydromyricetin amagwiritsidwa ntchito makamaka ngati chithandizo chamankhwala, koma angagwiritsidwenso ntchito pochiza matenda opuma, uchidakwa wa mankhwala a Chinese patent mankhwala, monga mapiritsi, makapisozi, ndi granules.

1. Zakumwa Zogwira Ntchito ndi Zowonjezera

Chifukwa cha chiwindi - kuteteza ndi anti-hangover katundu,Dihydromyricetin ufa ndi chinthu chodziwika bwino muzakumwa zogwira ntchito. Ikhoza kuwonjezeredwa ku zakumwa pamagulu a 0.2 - 1g / L, kupatsa ogula njira yabwino yotetezera chiwindi chawo atamwa mowa. M'zakudya zowonjezera, nthawi zambiri amapangidwa kukhala makapisozi kapena mapiritsi, ndi mlingo wa 200 - 500mg pa kutumikira, kuyang'ana anthu omwe ali ndi thanzi labwino omwe akufuna kupititsa patsogolo ntchito yawo ya chiwindi ndi thanzi labwino.

2. Makampani Opanga Mankhwala

Pazamankhwala, DHM ikuwonetsa kuthekera kwakukulu. Mphamvu yake ya antioxidant ndi anti-inflammatory effect imapangitsa kuti ikhale yofunika kwambiri mu mankhwala ochizira matenda a chiwindi. Zitha kupangidwa kukhala zopangira pakamwa, ndi mlingo wa tsiku ndi tsiku wa 300 - 600mg, kuti athandize kukonza maselo a chiwindi ndi kusintha ntchito ya chiwindi. Kuphatikiza apo, mphamvu zake zoteteza mitsempha zimatha kuthandizira kupanga mankhwala a matenda a neurodegenerative, ngakhale kufufuza kwina kukuchitikabe.

3. Cosmetics Field

Mphamvu yabwino kwambiri ya antioxidant ya Dihydromyricetin imamuthandiza kulimbana ndi ma free radicals, ndikupangitsa kuti ikhale yoyenera zodzoladzola zoletsa kukalamba. Itha kuwonjezeredwa ku zonona, seramu, ndi mafuta odzola pamlingo wa 1 - 5%. Zimathandiza kuchepetsa maonekedwe a makwinya, kusintha khungu, komanso kuteteza khungu ku kuwonongeka kwa chilengedwe. Kuphatikiza apo, anti-inflammatory properties amathanso kukhala opindulitsa pazinthu zosamalira khungu, kutonthoza khungu lokwiya komanso kuchepetsa kufiira.

4. Food Industry monga Antioxidant

Monga antioxidant zachilengedwe, DHM itha kugwiritsidwa ntchito m'makampani azakudya kuti awonjezere moyo wa alumali wazakudya. Ikhoza kuwonjezeredwa ku mafuta odyedwa, nyama yokonzedwa, ndi zokhwasula-khwasula. Mwachitsanzo, mumafuta odyedwa, kuwonjezera pang'ono (0.01 - 0.05%) kumatha kuletsa bwino lipid oxidation, kusunga mtundu ndi kukoma kwamafuta, komanso kupatsanso ogula zowonjezera zaumoyo.

5. Chakudya Chanyama Chowonjezera

Paulimi, Dihydromyricetin itha kugwiritsidwa ntchito ngati chowonjezera cha ziweto. Ndi mulingo wowonjezera wa 10 - 20mg/kg mu chakudya cha ziweto, ukhoza kupititsa patsogolo chitetezo cha nyama, kupititsa patsogolo kakulidwe kake, ndi kuchepetsa kuchuluka kwa matenda. Izi sizimangopindulitsa thanzi la nyama komanso zimakhala ndi zotsatira zabwino pa khalidwe ndi chitetezo cha mankhwala opangidwa ndi zinyama.

Malingaliro a Toxicological

Zithunzi za KINTAI Dihydromyricetin ufa akuwonetsa kawopsedwe wochepa kwambiri. Kafukufuku wa zinyama awonetsa kuti mtengo wapakamwa wa LD₅₀ umaposa 2000 mg/kg, zomwe zikuwonetsa chiopsezo chochepa cha kuvulala koopsa pamilingo yogwiritsiridwa ntchito bwino. Palibe zotsatira zoyipa zomwe zanenedwapo pakugwiritsa ntchito kwa anthu mkati mwa mlingo wovomerezeka. Ngakhale kuwonetseredwa kosatha kumawonedwa kukhala kotetezeka, kudya kwambiri kungayambitse zizindikiro zochepa monga kusapeza bwino m'mimba kapena nseru mwa anthu ena omwe ali ndi vuto. Kuteteza moyo wa ogula, KINTAI nthawi zonse imayesa mayeso a kawopsedwe, ndikuwonetsetsa kutsatira mosamalitsa malamulo achitetezo.

Kuwongolera Kwabwino & Zitsimikizo Zachitetezo

Wopangidwa m'malo omwe amatsatira mokwanira miyezo ya Good Manufacturing Practice (GMP), DMY ya KINTAI nthawi zonse imakhala ndi chiyero cha ≥98%, monga zatsimikiziridwa molondola ndi High - Performance Liquid Chromatography (HPLC). Gulu lililonse limayesedwa mosamalitsa zitsulo zolemera, zokhala ndi malire pa Pb ≤2ppm ndi As ≤1ppm. Kuphatikiza apo, zotsalira zosungunulira ndi chitetezo cha ma microbial zimawunikidwa mwamphamvu. Satifiketi yatsatanetsatane ya Analysis (COA) ndi Material Safety Data Sheet (MSDS) zimaperekedwa pagulu lililonse, kutsimikizira kutsata miyezo yachitetezo chapadziko lonse lapansi yokhazikitsidwa ndi FDA, EFSA, ndi WHO.

Machenjezo Achitetezo & Zochepa

• Zoyipa: Chifukwa chosakwanira deta yachitetezo, Dihydromyricetin ufa sikuvomerezeka kwa amayi apakati kapena oyamwitsa popanda kukaonana ndi dokotala.
• Zoyipa: Kudya mopitirira muyeso kungapangitse kuti m'mimba musamve bwino. Ngati kusapeza kulikonse kapena zoyipa zimachitika, kusiya kugwiritsa ntchito nthawi yomweyo kumalangizidwa.
• Kusamalira: Kupewa kuthekera kupuma mkwiyo, mwachindunji mpweya ufa ayenera kupewedwa. Ndi bwino kusamalira ufa bwino - mpweya madera. Sungani mankhwalawa pamalo ozizira, owuma, otetezedwa ku dzuwa kuti likhalebe labwino komanso lokhazikika.

1. Timalonjeza kuti zopangira zathu zimakula mwachilengedwe popanda zowonjezera.
2. Timapereka njira zopangira makonda kuti apange Dihydromyricetin.
3. Malo athu opangira zinthu amakhala ndi ziphaso zovomerezeka padziko lonse lapansi kuphatikiza GMP, ISO 9001, ISO 22000, HACCP, KOSHER, ndi HALAL.

Q1: Dzina lina la dihydromyricetin ndi liti?

A1:Ampelopsin, yomwe imadziwikanso kuti dihydromyricetin ndi DHM, ikagwiritsidwa ntchito ngati mankhwala azitsamba, ndi flavanonol, mtundu wa flavonoid.

Q2: Kodi DMY imathandizira ndi vuto la kukomoka?

A2: Amadziwika kwa zaka mazana ambiri muzamankhwala achi China ngati mankhwala akupha poyizoni wa mowa komanso kuledzera.